PROBLEM TO BE SOLVED: To provide a novel antiinflammatory agent, IL-8 production inhibitor, and TNF-α production inhibitor.SOLUTION: The present invention provides an antiinflammatory agent, IL-8 production inhibitor, and TNF-α production inhibitor comprising a seed extract of passion fruit, which is a fruit of Passiflora (Passifloraceae), or isorhapontigenin represented by the following formula, as an active ingredient.COPYRIGHT: (C)2016,JPO&INPIT【課題】新規な抗炎症剤、IL-8産生阻害剤、及びTNF-α産生阻害剤の提供。【解決手段】トケイソウ科トケイソウ属の果物であるパッションフルーツの種子エキス又は下式で示されるイソラポンチゲニンを有効成分として含有する、抗炎症剤、IL-8産生阻害剤、及びTNF-α産生阻害剤。【選択図】なし