PROCEDE DE PREPARATION DE DERIVES DE 3-PHENYL/HETEROARYL-6-PHENOXY-8-ALKYLAMINO-IMIDAZO[1,2-B]PYRIDAZINE

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专利权人:

BAYER PHARMA AKTIENGESELLSCHAFT

发明人:

PAULSEN, HOLGER,MUNSTER, UWE,GUIMOND, NICOLAS

申请号：

CA2959224

公开号：

CA2959224A1

申请日:

2015.08.28

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

A process for the preparation of 3-phenyl/heteroaryl-6-phenoxy-8-alkylamino-imidazo[1,2-b]pyridazine derivatives and intermediates of this process. A crystalline form of N-cyclopropyl-4-{6-(2,3-difluor-4-methoxyphenoxy)-8-[(3,3,3-trifluorpropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-2-methylbenzamide. The compounds are inhibitors of the Mps-1 kinase (Monopolar Spindle 1 kinase； also known as Tyrosine Threonine Kinase, TTK).

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