POLYEPITOPE CHIMERIQUE DU VIRUS DE LA DENGUE COMPOSE DE FRAGMENTS DE PROTEINES NON STRUCTURALES ET SON UTILISATION DANS UNE COMPOSITION IMMUNOGENE CONTRE UNE INFECTION PAR LE VIRUS DE LA DENGUE农业专利-农业专业知识服务系统

发明人:: TANGY, FREDERIC,SAKUNTABHAI, ANAVAJ,SIMON-LORIERE, ETIENNE,ROTH, CLAUDE,BUCHY, PHILIPPE

摘要：: The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means, in particular polynucleotides, vectors, cells and methods to produce vectors expressing said chimeric polyepitopes, in particular vectors consisting of recombinant measles virus (MV) particles. The present invention also relates to the use of the recombinant MV particles, in particular under the form of a composition or of a vaccine, for the prevention and/or treatment of a dengue virus infection.