A DENGUE VIRUS CHIMERIC POLYEPITOPE COMPOSED OF FRAGMENTS OF NON STRUCTURAL PROTEINS AND ITS USE IN AN IMMUNOGENIC COMPOSITION AGAINST DENGUE VIRUS INFECTION农业专利-农业学术服务平台

发明人:: TANGY FRÉDÉRIC,SHAKUNTABAI ANAVAJ,SIMON LORIERE ETIENNE,ROTH CLAUDE,BUCHY PHILIPPE

摘要：: The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means in particular polynucleotides vectors cells and methods to produce vectors expressing said chimeric polyepitopes in particular vectors consisting of recombinant measles virus (MV) particles. The present invention also relates to the use of the recombinant MV particles in particular under the form of a composition or of a vaccine for the prevention and/or treatment of a dengue virus infection.