Daniel KWAN,David Burgin BURGIN,Stephen Gavin HACKETT
申请号：
US15562085
公开号：
US20180073089A1
申请日:
2016.03.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to recombinant clostridial neurotoxins which have been modified to improve their activation. In particular, the present invention relates to chimeric clostridial neurotoxins in which the activation loop has been replaced by the activation loop from a different subtype within the same serotype. The present invention also relates to methods of producing such chimeric clostridial neurotoxins and methods of activating such modified clostridial neurotoxins, as well as polynucleotides, vectors and cells expressing such chimeric clostridial neurotoxins, compositions comprising such chimeric clostridial neurotoxins and uses thereof.
