Julien Alistair Brown,Mark Daniel Calmiano,Elizabeth Pearl Jones,Boris Kroeplien,James Thomas Reuberson,Matthew Duncan Selby,Michael Alan Shaw,Zhaoning Zhu
申请号：
US15039092
公开号：
US10004737B2
申请日:
2014.12.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A series of substituted benzimidazole, imidazo[1,2-α]pyridine and pyrazolo[1,5-α]pyridine derivatives, and analogs thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders.
