Rikki Peter Alexander,Jonathan Mark Bentley,Gareth Neil Brace,Daniel Christopher Brookings,Prafulkumar Tulshibhai Chovatia,Hervé Jean Claude Deboves,Craig Johnstone,Elizabeth Pearl Jones,Boris Kroepli
申请号:
US15100825
公开号:
US09868749B2
申请日:
2014.12.08
申请国别(地区):
US
年份:
2018
代理人:
摘要:
A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.