HAHM, JONG CHEON,PARK, BYUNG YOUNG,PARK, EUN KYU,LEE, HEE SUK,KIM, MIN-YOUNG
申请号：
CA2696207
公开号：
CA2696207C
申请日:
2008.08.25
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to an ethyl acetate fraction of Melissa leafhaving excellent an- giogenesis and MMPinhibitory activities, and a composition comprising the same. In particular,the ethyl acetate fraction of Melissa leaf is characterizedthat Melissa leaf is extracted with 50-100% C1-C6 alcohol, and concentrated,and then the concentrated alcohol extract is suspendedin water, and fractionated with ethyl acetate, and dried to obtain the ethylacetate fraction of Melissa leaf. The ethyl acetate fractionof Melissa leaf of the present invention has strong and excellent anti-angiogenic and MMP inhibitory activities. Therefore, thecomposition comprising the ethyl acetate fraction of Melissa leaf of thepresent invention can be used as an agent for the treatmentor prevention of angiogenesis -related diseases and MMP-mediated diseases.
