A blank (2') from which a dental prosthesis (e.g. crown, abutment, bridge or denture) 32 can be formed. The blank (2') comprises a main body portion (4), the main body portion (e.g. a substantially cylindrical pre-turned component made of steel or titanium or polyetheretherketone (PEEK) or combinations thereof having an axis of elongation (10), a first end (11) and a second end (17). The blank (2') further comprises a registration portion (13) at the first end (11), for aligning, in use, the dental prosthesis (32) in a precise position and/or orientation on an implant. The blank (2') further comprises an attachment portion (6') at the second end (17), the attachment portion (6') including a first bore (34) for enabling secure attachment of the blank (2') to a holder (56) during machining and/or milling of the blank, an attachment axis (36) being defined by the first bore (34)； wherein the attachment axis (36) is at an angle (e.g. right angle) to the axis of elongation (10). The attachment portion (6') may be in the form of a (e.g. axially-extending) flat tab that includes first (38) and second (40) registration surfaces on opposite sides of the attachment portion (6'), the first registration surface (38) and/or the second registration surface (40) extending parallel to the axis of elongation (10). Also disclosed is a method of manufacturing a dental prosthesis, comprising: providing the blank (2') as aforesaid； providing a holder (56), the holder including a fixing arrangement (58) configured to engage the attachment portion (6') of the blank (2')； mounting the blank (2') to the holder (56)； milling at least a portion of the outer part of the main body portion (4) so as to form the shape of the dental prosthesis (32)； and forming a second bore (8') in the main body portion, the second bore extending at an angle of inclination (a) to the axis of elongation (10). The angle of inclination (a) may be in the range 20-40 degrees, more preferably 25-35 degrees, more prefer
