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Methods of isolating T cells having antigenic specificity for a cancer-specific mutation
专利权人:
The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Tran, Eric,Lu, Yong-Chen,Robbins, Paul E.,Rosenberg, Steven A.
申请号:
AU2014407540
公开号:
AU2014407540A1
申请日:
2014.10.02
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
Disclosed are methods of isolating T cells having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous APCs of the patient to present the mutated amino acid sequence; co-culturing autologous T cells of the patient with the autologous APCs that present the mutated amino acid sequence; and selecting the autologous T cells. Also disclosed are related methods of preparing a population of cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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