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ANTINEOPLASTIC COMBINATIONS CONTAINING HKI-272 AND VINORELBINE
专利权人:
УАЙТ ЭлЭлСи (US)
发明人:
ЗАХАРЧУК Чарльз (US)
申请号:
RU2013126140/15
公开号:
RU2013126140A
申请日:
2013.06.06
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating a neoplasm in a subject, wherein said method comprises administering vinorelbine or its analogue and administering HKI-272 or its analogue. The treatment method according to claim 1, where the stages of administration are carried out simultaneously, sequentially, jointly, in a specific order or according to a specific time dependence. The treatment method according to claim 1, wherein said vinorelbine or its analogue is administered in a single dose. The treatment method according to claim 1, wherein said HKI-272 or an analog thereof is administered in a single dose. The treatment method according to claim 1, wherein said vinorelbine or its analogue means vinorelbine. The treatment method according to claim 1, wherein said HKI-272 or an analogue thereof means HKI-272.7. The treatment method according to claim 1, where one or both of these components, i.e. vinorelbine or its analogue and HKI-272 or its analogue are administered intravenously to said subject. 8. The treatment method according to claim 1, where one or both of these components, i.e. vinorelbine or its analogue and HKI-272 or its analogue are administered orally to said subject. The treatment method according to claim 1, where the specified neoplasm is associated with excessive expression or amplification of HER-2.10. The treatment method according to claim 1, wherein said neoplasm is metastatic. The treatment method according to claim 1, wherein said neoplasm is selected from the group consisting of lung cancer, breast cancer, myeloma, prostate cancer, cancer of the head and neck, transitional cell carcinoma, small cell neuroendocrine carcinoma of the cervix uteri and large cell neuroendocrine carcinoma of the cervix. . The treatment method according to claim 11, wherein said neoplasm is breast cancer. The treatment method of claim 12, wherein said breast cancer is HER-2-positive breast cancer with metastases. C�1. Способ лечения новообразования у субъекта, где указанныйспособ вк
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