isolated peptide epitope, recombinant protein, isolated nucleic acid molecule, vector, host cell, method for preparing peptide or mutant epitope, protein vaccine, use of peptide or mutant epitope, gene vaccine, use nucleic acid molecule, pharmaceutical composition, monoclonal antibody and antigen-binding fragment thereof, hybridoma cell line, kit, method for detecting the presence or level of hbsag protein in a sample and use of the monoclonal antibody or fragment of antigen binding
XIAMEN INNOVAX BIOTECH CO., LTD.;XIAMEN UNIVERSITY
发明人:
JUN ZHANG,NINGSHAO XIA,QUAN YUAN,TIANYING ZHANG,WENXIN LUO,YIXIN CHEN
申请号：
BR112014030797
公开号：
BR112014030797A2
申请日:
2013.06.06
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract “isolated peptide epitope, recombinant protein, isolated nucleic acid molecule, vector, host cell, method for preparing peptide or mutant epitope, protein vaccine, use of peptide or mutant epitope, gene vaccine , use of nucleic acid molecule, pharmaceutical composition, monoclonal antibody and antigen binding fragment thereof, hybridoma cell line, kit, method for detecting the presence or level of hbsag protein in a sample and use of monoclonal antibody or antigen-binding fragment thereof "The present invention relates to peptide epitopes (or mutants thereof) for the treatment of hepatitis b virus infection, recombinant proteins comprising said peptide epitopes (or mutants thereof) and carrier proteins, and uses of such peptide epitopes (or mutants thereof) and recombinant proteins. The present invention also relates to antibodies against said peptide epitopes, antibody producing cell lines, and uses thereof. furthermore, the present invention relates to vaccines or pharmaceutical compositions for the treatment or alleviation of one or more symptoms associated with hepatitis b virus infection which comprise the recombinant proteins or antibodies according to the invention respectively.resumo “epítopo de peptídeo isolado, proteína recombinante, molécula de ácido nucléico isolada, vetor, célula hospedeira, método para preparar o epítopo de peptídeo ou mutante do mesmo, vacina de proteína, uso do epítopo de peptídeo ou mutante do mesmo, vacina de gene, uso da molécula de ácido nucléico, composição farmacêutica, anticorpo monoclonal e um fragmento de ligação ao antígeno do mesmo, linha de célula de hibridoma, kit, método para detecção da presença ou nível da proteína hbsag em uma amostra e uso do anticorpo monoclonal ou fragmento de ligação ao antígeno do mesmo” a presente invenção refere-se aos epítopos dos peptídeos (ou mutantes dos mesmos) para o tratamento da infecção pelo vírus da hepatite b, proteínas recombinantes compreendendo os referidos epítopos de p
