Maria Gonzalez Ferreiro,Christoph Dunmann,Lutz Kroehne,Andreas Voigt
申请号：
US13122501
公开号：
US20120058151A1
申请日:
2009.10.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a method for the production of a nanoparticulate pharmaceutical composition. The method comprises the steps of a) suspending in water a poorly soluble active ingredient without the presence of a detergent, b) mechanically treating said suspension to obtain particles comprising the active ingredient with an effective average size of less than about 5000 nm, c) contacting said active ingredient or suspension with a first polyelectrolyte during and/or before mechanically treating, d) optionally contacting said suspension with a one or more second or further polyelectrolytes during, before and/or after mechanically treating, e) optionally drying said suspension. The invention also pertains to the pharmaceutical compositions obtained by the method of the invention.
