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PREPARATIONS SOLIDES ENDUITES D'ACIDE VALPROIQUE
专利权人:
TORAY INDUSTRIES; INC.
发明人:
HAYASHI, YUKI,YOSHII, RYOJI,HORIUCHI, YASUHIDE
申请号:
CA2750209
公开号:
CA2750209C
申请日:
2010.03.03
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The present invention provides a coated solid preparation applicable to a one-dosepack, wherein, even when the preparation is in an unpacked state, thestability againstmoisture of valproic acid or a pharmacologically acceptable salt thereofcontained therein ismaintained and the deliquescence is suppressed. The present invention providesa coatedsolid preparation which contains, as an active ingredient, valproic acid or apharmacologicallyacceptable salt thereof and is coated with a coating layer containingpolyvinyl alcohol andswelling clay, wherein the mass ratio of the polyvinyl alcohol to the swellingclay is 8:2 to 3:7and the swelling clay is dispersed as a laminated structure. The polyvinylalcohol and theswelling clay occupy 88 mass percent or more of the coating, and the swellingclay isbentonite or magnesium aluminum silicate. Other ingredient(s) in thepreparation are one ormore pharmaceutical excipient(s).
来源网站:
中国工程科技知识中心
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