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JAK1 inhibitors for the treatment of myelodysplastic syndromes
- 专利权人:
- Incyte Corporation
- 发明人:
- VADDI, Krishna
- 申请号：
- ES15710994
- 公开号：
- ES2688553T3
- 申请日:
- 2015.02.27
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- A selective JAK1 inhibitor selected from: 3- [1- (6-chloropyridin-2-yl) pyrrolidin-3-yl] -3- [4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl ) -1H-pyrazol-1-yl] propanonitrile； 3- (1- [1,3] oxazolo [5,4-b] pyridin-2-ylpyrrolidin-3-yl) -3- [4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl ) -1H-pyrazol-1-yl] propanonitrile； 4 - [(4- {3-cyano-2- [4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl] propyl} piperazin-1-yl) carbonyl] -3-fluorobenzonitrile； 4 - [(4- {3-cyano-2- [3- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrrol-1-yl] propyl} piperazin-1-yl) carbonyl] -3-fluorobenzonitrile； {1- {1- [3-Fluoro-2- (trifluoromethyl) isonicotinoyl] piperidin-4-yl} -3- [4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H- pyrazol-1-yl] azetidin-3-yl} acetonitrile； 4- {3- (cyanomethyl) -3- [4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl] azetidin-1-yl} -N- [ 4-fluoro-2- (trifluoromethyl) phenyl] piperidine-1-carboxamide； [3- [4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl] -1- (1 - {[2- (trifluoromethyl) pyrimidin-4-yl ] carbonyl} piperidin-4-yl) azetidin-3-yl] acetonitrile； [trans-1- [4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl] -3- (4 - {[2- (trifluoromethyl) pyrimidin-4 - il] carbonyl} piperazin-1-yl) cyclobutyl] acetonitrile； {trans-3- (4 - {[4 - [(3-hydroxyazetidin-1-yl) methyl] -6- (trifluoromethyl) pyridin-2-yl] oxy} piperidin-1-yl) -1- [4- (7H-pyrrolo [2,3- d] pyrimidin-4-yl) -1 H -pyrazol-1-yl] cyclobutyl} acetonitrile； {trans-3- (4 - {[4 - {[(2S) -2- (hydroxymethyl) pyrrolidin-1-yl] methyl} -6- (trifluoromethyl) pyridin-2-yl] oxy} piperidin-1-yl ) -1- [4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl] cyclobutyl} acetonitrile； {trans-3- (4 - {[4 - {[(2R) -2- (hydroxymethyl) pyrrolidin-1-yl] methyl} -6- (trifluoromethyl) pyridin-2-yl] oxy} piperidin-1-yl ) -1- [4- (7H25 pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl] cyclobutyl} acetonitrile； 4- (4- {3 - [(dimethylamino) methyl] -5-fluorophenoxy} piperidin-1-yl) -3- [4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl)
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
