PROBLEM TO BE SOLVED: To provide a composition which enables homeostatic control of postprandial glucose levels while reducing the risk of hypoglycemia, and enables excellent control in blood glucose levels mimicking the insulin release kinetics of a non-diabetic individual.SOLUTION: The invention relates to a composition which is suitable for pulmonary administration, increases to a peak of serum insulin concentration within 15 minutes from administration and decreases to a half maximal level within 80 minutes from administration, is capable of suppressing postprandial blood glucose fluctuation, as well as consists of microparticles comprising diketopiperazine and insulin. The invention also relates to a method for administering the insulin composition within approximately 10 minutes prior to beginning a meal to approximately 30 minutes after beginning a meal.【課題】低血糖症のリスクを抑える一方で、食後血糖値のホメオスタシス制御を可能にして、非糖尿病個体のインスリン放出動態を模倣した血糖値の優れたコントロールを可能にする組成物の提供。【解決手段】肺投与に適していて、投与後１５分以内にピークに到達し投与後８０分以内に半最大値まで低下する血清インスリン濃度をもたらし、食後血糖変動を抑えることが可能な、ジケトピペラジンとインスリンを含む微粒子からなる組成物。前記インスリン組成物を、食事の開始に先立つ１０分前から食事の開始後３０分以内に投与するインスリン組成物の投与方法。【選択図】なし
