WATANABE, MASASHI,OKACHI, TAKAHIRO,KAWAHARA, MICHIAKI,NAGASAWA, HIROSHI,SATO, NORITADA,TAKITA, TAKASHI,HASEGAWA, GEN
申请号：
CA2908879
公开号：
CA2908879A1
申请日:
2014.04.07
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Provided are an intermediate in the manufacture of an atropisomer of a dipyrromethene that has excellent mineralocorticoid receptor antagonism, a method for manufacturing the same and crystals thereof. A method for manufacturing an atropisomer of a dipyrromethene that includes the step of dividing the atropisomer of general formula (I) [In the formula, R1 is a methyl group or a trifluoromethyl group, R2 is a hydrogen atom or a C1-C3 alkoxy group, and n is an integer selected from 1 to 3.] characterized by using an optically active amine that has a cinchonan skeleton, and crystals of (S)-1-(2- hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-( trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.
