YODER, NICHOLAS C.,BAI, CHEN,MILLER, MICHAEL LOUIS
申请号：
CA2988806
公开号：
CA2988806A1
申请日:
2016.06.28
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.
