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6-Cycloalkyl-pyrazolopyrimidinones for the Treatment of CNS Disorders
专利权人:
Niklas Heine;Gerhard Schaenzle;Christian Eickmeier;Marco Ferrara;Holger Rosenbrock;Riccardo Giovannini
发明人:
Niklas Heine,Christian Eickmeier,Marco Ferrara,Riccardo Giovannini,Holger Rosenbrock,Gerhard Schaenzle
申请号:
US13206633
公开号:
US20120202829A1
申请日:
2011.08.10
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to novel 6-Cycloalkyl-pyrazolopyrimidinones according to formula (I).wherein R1 is a 5 or 6 membered aromatic heteroaryl-group, R2 is an optional substituent, D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl, m=1 or 2 and n is 0, 1 or 2.The new compounds are for use as the active entity of medicaments or for the manufacture of medicaments respectively, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may for example be associated with Alzheimer's disease, schizophrenia and other diseases. The new compounds are also for example for the manufacture of medicaments and/or for use in the treatment of these diseases, in particular for cognitive impairment associated with such disease. The compounds of the invention show PDE9 inhibiting properties.
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