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6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
HEINE, NIKLAS,GIOVANNINI, RICCARDO
申请号:
TW101104800
公开号:
TW201247672A
申请日:
2012.02.14
申请国别(地区):
TW
年份:
2012
代理人:
摘要:
The invention relates to novel pyrazolopyrimidinones according to formula (I). wherein X is CRe or unsubstituted N, D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl, Ra, Rb, Rc, Rd, Re are either H or optional substituents, m= 1 or 2 and n is 0, 1 or 2. The new compounds are for use as the active entity of medicaments or for the manufacture of medicaments respectively, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may for example be associated with Alzheirmers disease, schizophrenia and other diseases. The new compounds are also for example for the manufacture of medicaments and/or for use in the treatment of these diseases, in particular for cognitive impairment associated with such disease. The compounds of the invention show PDE9 inhibiting properties.
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