Dana-Farber Cancer Institute, Inc.;達納-法伯癌症研究所股份有限公司
发明人:
BRADNER, James, E.,QI, Jun,TANAKA, Minoru,BUCKLEY, Dennis
申请号:
HK18115549
公开号:
HK1256417A1
申请日:
2018.12.05
申请国别(地区):
HK
年份:
2019
代理人:
摘要:
The present invention provides compounds and pharmaceutically compositions thereof. The compounds and compositions are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.