БРАДНЕР Джеймс И. (US),ЦИ Цзюнь (US),ТАНАКА Минору (US),БАКЛИ Деннис (US)
申请号：
RU2018112961
公开号：
RU2018112961A
申请日:
2016.09.09
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
The present invention provides compounds and pharmaceutically compositions thereof. The compounds and compositions are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.
