COMPOSITION FOR ELICITING A SPECIFIC CTL RESPONSE, COMPRISING A LYMPHO-ABLATIVE COMPOUND AND A MOLECULE THAT CONTAINS ANTIGENIC SEQUENCES AND TARGETS PROFESSIONAL ANTIGEN PRESENTING CELLS
The present invention relates to a composition for eliciting a specific cytotoxic T lymphocyte (CTL) response against T cell epitopes in a mammal, which comprises a compound provoking lymphocytopenia, a molecule having selective affinity for professional antigen presenting cells (APC), wherein said molecule is associated to said T cell epitope, and optionally, a pharmaceutical acceptable carrier. Advantageously, the composition further contains a CpG adjuvant. Said composition may be used in anti-infectious and anti-cancer therapies.本發明關於一種用於引發一哺乳類中對抗T細胞抗原決定基之特異性細胞毒性T淋巴細胞(CTL)反應的組成物,其包含:一個引起淋巴細胞減少症之化合物、一個對專業化抗原呈現細胞(APC)具有選擇性親和力的分子,其中該分子係與該T細胞抗原決定基相關連,以及任擇地一藥學上可接受之載劑。有利地,該組成物進一步含有一CpG佐劑。該組成物可被用於抗感染及抗癌療法。
