PHARMACEUTICAL COMPOSITIONS AND HEALTH FUNCTIONAL FOODS COMPOSITIONS FOR THE IMPROVEMENT OF LIVER FUNCTIONS CONTAINING COMPOUND ISOLATED FROM YOUNGIA DENTICULATA AS AN ACTIVE INGREDIENT
한국과학기술연구원;KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
NHO, CHU WON,노주원,LEE, SAET BYOUL,이샛별,YUN, JI HO,윤지호,JUNG, SANG HOON,정상훈,LEE, HEE JU,이희주,KANG, KYUNG SU,강경수,YOO, JI HYE,유지혜,KIM, MYUNG SOO,김명수,AHN, SOO YOUNG,안수용,KIM, JONG HWAN,김종환
申请号：
KR1020120024051
公开号：
KR1020120031041A
申请日:
2012.03.08
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A pharmaceutical composition and a health supplement for liver function improvement containing a compound isolated from youngia denticulata as an active ingredient are provided to increase activity of detoxification enzyme of liver including Quinone reductase and Antioxidant response element. CONSTITUTION: A pharmaceutical composition and a health supplement for liver function improvement containing a compound isolated from youngia denticulata as an active ingredient comprises a compound which is represented by chemical formula 3,4, or 5 as active ingredients. The compound of chemical formula 3,4, or 5 is Youngiaside A, Youngiaside B, and Youngiaside C. A health supplement composition for liver function improvement comprises compound of the chemical formulas of 3,4, or 5. The compound of chemical formula 3, 4, or 5 detoxifies carcinogenic materials by multiplying activity of quinone reductase. The compound of chemical formula 3, 4, or 5 also detoxifies carcinogenic materials by multiplying activity of the oxygen-resistant response factor(ARE) which induces activity of 2 phase detoxifying enzyme system.본 발명은 이고들빼기(Youngia denticulata)로부터 분리한 화합물인 영지아사이드 A(Youngiaside A), 영지아사이드 B(Youngiaside B), 영지아사이드 C(Youngiaside C)로 구성되는 군으로부터 선택되는 하나 이상의 화합물을 유효성분으로 함유하는 간 기능 개선용 약학적 조성물 또는 식품 조성물에 관한 것으로, 본 발명에 따른 이고들빼기로부터 분리된 화합물은 암 예방 지표효소인 퀴논 리덕타아제(Quinone reductase, QR)와 항산화 반응인자인 항산화반응인자(Antioxidant response element, ARE)를 비롯한 간의 해독효소의 활성을 증진시키고, 세포 독성이 없을 뿐만 아니라, 에탄올과 아세트아미노펜에 의해 유도되는 간손상으로부터 간을 보호하므로, 본 발명에 따른 조성물은 간 기능 개선을 위한 의약품, 건강기능식품에 유용하게 사용될 수 있다.
