您的位置: 首页 > 农业专利 > 详情页

Conjugate comprising a neurotensin receptor ligand
专利权人:
发明人:
申请号:
EP14001992.8
公开号:
EP2954933A1
申请日:
2014.06.10
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The present invention is related to a conjugate comprising a structure of general formula (I)        [TM1] - [AD1] - [LM] - [AD2] - [TM2]     (I),whereinTM1 is a first targeting moiety, wherein the first targeting moiety is capable of binding to a first target,AD1 is a first adapter moiety or is absent,LM is a linker moiety or is absent,AD2 is a second adapter moiety or is absent, andTM2 is a second targeting moiety, wherein the second targeting moiety is capable of binding to a second targetwherein the first targeting moiety and/or the second targeting moiety is a compound of formula (II):whereinR1 is selected from the group consisting of hydrogen, methyl and cyclopropylmethylAA-COOH is an amino acid selected from the group consisting of 2-amino-2-adamantane carboxylic acid, cyclohexylglycine and 9-amino-bicyclo[3.3.1]nonane-9-carboxylic acidR2 is selected from the group consisting of (C1-C6)alkyl, (C3-C8)cycloalkyl, (C3C8)cycloalkylmethyl, halogen, nitro and trifluoromethylALK is (C2-C5)alkylideneR3, R4 and R5 are each and independently selected from the group consisting of hydrogen and (C1-C4)alkyl under the proviso that one of R3, R4 and R5 is of the following formula (III)whereinALK is (C2-C5)alkylideneR6 is selected from the group consisting of hydrogen and (C1-C4)alkyl andR7 is a bondor a pharmacologically acceptable salt, solvate or hydrate thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充