This invention is not included the solvent substantially, being the nano dispersion liquid of the substrate medium active ingredient, the substrate is soluble in the pH inside intestine, but the intestinal solubility substrate which is insoluble in the pH of stomach is included, the intestinal solubility substrate is not included, the nano dispersion liquid, or the solvent which the nano dispersion liquid occupies 50 weight % at least substantially, preparation manner of the nano dispersion liquid of the substrate medium active ingredient is offered.本発明は、溶媒を実質的に含まない、担体中活性成分のナノ分散液であって、担体は、腸内pHにおいて可溶であるが、胃のpHにおいて不溶である腸溶性担体を含み、腸溶性担体は、ナノ分散液の少なくとも50重量%を占めるナノ分散液、および溶媒を実質的に含まない、担体中活性成分のナノ分散液の調製方法を提供する。
