The present invention relates to formula (I) compounds, and wherein X, R1, R2, R3, R4 and R5 are as defined herein, there is the disease of response to CXCR2 receptor modulators with what treatment. The method for also describing the pharmaceutical composition comprising the compound and preparing the compound.本發明涉及式(I)化合物,其中X、R1、R2、R3、R4和R5如本文所定義,其用於治療對CXCR2受體調節劑有響應的疾病。還描述了包含所述化合物的藥物組合物以及製備所述化合物的方法。