PROBLEM TO BE SOLVED: To provide an insulin secretagogue which is effective in preventing diabetes and the like and which is very safe and free of concern of side effects even when ingested continuously.SOLUTION: This insulin secretagogue contains, as an active ingredient, an HLB-4 to 15 polyglycerin fatty acid ester, and is therefore very safe and free of concern of side effects even when ingested continuously. It is preferable that the insulin secretagogue contains glycerin fatty acid ester along with fat and oil. Alternatively the insulin secretagogue may be used along with fat and oil.COPYRIGHT: (C)2012,JPO&INPIT【課題】安全性が高く、継続的に摂取しても副作用の懸念がない、糖尿病の予防等に有効なインスリン分泌促進剤を提供すること。【解決手段】本発明のインスリン分泌促進剤は、HLB4~15のポリグリセリン脂肪酸エステルを有効成分として含有するので、安全性が高く、継続的に摂取しても副作用の懸念がない。本発明のインスリン分泌促進剤では、上記ポリグリセリン脂肪酸エステルを油脂とともに含有することが好ましい。また、油脂と併用されてもよい。【選択図】図1