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Carboxylic acid compound
专利权人:
Ryutaro Nakashima;Narihiro Toda;Takeshi Honda;Masao Yoshida;Rieko Takano;Masahiro Inoue;Koji Matsumoto
发明人:
Narihiro Toda,Masao Yoshida,Rieko Takano,Masahiro Inoue,Takeshi Honda,Koji Matsumoto,Ryutaro Nakashima
申请号:
US12893592
公开号:
US08222281B2
申请日:
2010.09.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
To find a therapeutic agent and/or a preventive agent for diabetes mellitus or the like having excellent activity and safety. A compound represented by the following general formula (I), or a pharmacologically acceptable salt thereof. In the formula, X represents ═C(R5)- or ═N—; Y represents —O— or —NH—; L represents a bond or a substitutable C1-C3 alkylene group; M represents a substitutable C3-C10 cycloalkyl group, a substitutable C6-C10 aryl group, or a substitutable heterocyclic group; R1 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 aliphatic acyl group, a C1-C6 alkoxy C1-C6 alkyl group, or a C6-C10 aryl group; and R2, R3, R4, and R5 may be the same or different and each represent a hydrogen atom, a halogen atom, a C1-C3 alkyl group, a C1-C3 haloalkyl group, a C1-C3 alkoxy group, or a nitro group. In this connection, the alkyl group moieties of R1 and R2 may be bonded to each other to form a 5- to 6-membered heterocyclic ring containing one oxygen atom.
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