DAVIE, Rebecca Louise,EDWARDS, Hannah Joy,EVANS, David Michael,HODGSON, Simon Teanby,MILLER, Iain,NOVAK, Andrew Richard,SMITH, Alun John,STOCKS, Michael John
申请号：
ES14727034
公开号：
ES2626968T3
申请日:
2014.05.23
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of formula (I), ** Formula ** in which B is a fused 6,5- or 6,6-heteroaromatic bicyclic ring, containing N and, optionally, one or two additional heteroatoms independently selected from N, O and S, which is optionally mono, di or trisubstituted with a substituent selected from alkyl, alkoxy, OH, halo, CN, COOR8, CONR8R9, CF3 and NR8R9； wherein when B is a fused 6,5-heteroaromatic bicyclic ring, it is linked to -CONH- (CH2) - through its 6-member ring component； W, X, Y and Z are independently selected from C, N, O and S, so that the ring containing W, X, Y and Z is a five-membered aromatic heterocycle； wherein, R5, R6 and R7 are independently absent or independently selected from H, alkyl, halo, OH, aryl, heteroaryl, -NR8R9, CN, COOR8, CONR8R9, -NR8COR9, CF3 and R16； wherein at least one of R5, R6 and R7 is present and is independently selected from alkyl, halo, OH, aryl, heteroaryl, -NR8R9, CN, COOR8, CONR8R9, -NR8COR9, CF3 and R16； A is selected from aryl and heteroaryl； R8 and R9 are independently selected from H and alkyl； R16 is a 3, 4, 5 or 6 carbon monocyclic ring system that can be aromatic, saturated or unsaturated non-aromatic and can optionally contain 1, 2, 3 or 4 heteroatoms selected from N, O and S, wherein the R16 ring system is in turn optionally substituted with substituents selected from alkyl and oxo； the alkyl is a linear saturated hydrocarbon having up to 10 carbon atoms (C1-C10) or a branched saturated hydrocarbon of between 3 and 10 carbon atoms (C3-C10)； the alkyl may be optionally substituted with 1 or 2 substituents independently selected from (C1-C6) alkoxy, OH, CN, CF3, COOR10, CONR10R11, fluoro and NR10R11； the alkoxy is a linear hydrocarbon bonded through the O of between 1 and 6 carbon atoms (C1-C6) or a branched hydrocarbon bonded through the O of between 3 and 6 carbon atoms (C3-C6)； the alkoxy may be optionally substituted with 1 or 2 substituents independently selected from OH, CN, CF3, COOR10, CONR10R11, fluoro and NR10R1
