Relates to compounds of formula (i) wherein: R3 is c1-c6 alkyl, alkoxy alkyl of C1 - C6 C1 - C6, among others and (OR) is \u2013nr13c cr14 = chr15, among others, being Hydrogen or Methyl R13, R14 and R15 are Hydrogen, Methyl, among others R12 is Hydrogen Halo, among Others r1 is phenyl substituted 2 to 4 V ECES by Halo or c1-c6 alkoxy.Are specific Compounds, N - [2 - (6 - [3 - (2,6 - Dichloro - 3,5 - Dimethoxy - fenii) - 1 - methyl - 4 - ilamino ureido - pyrimidin-2-yl) - phenyl) - acrylamide n - [2 - (6 - [3 - (2,6 - Dichloro - 3,5 - Dimethoxy - phenyl) - 3 - methyl - 1 - pyridin - ureido] - pyrimidine - ilamino} - 4 - phenyl - acrylamide, among others. It also relates to a Pharmaceutical Composition and method of treatment.These compounds are inhibitors of fgfr4 being useful in the treatment of hepatocellular carcinomaSe refiere a compuestos de formula (I) donde: R3 es alquilo C1-C6, alcoxi C1-C6 - alquilo C1-C6, entre otros E es –NR13C(O)CR14=CHR15, entre otros, siendo R13 hidrogeno o metilo, R14 y R15 son hidrogeno, metilo, entre otros R12 es hidrogeno, halo, entre otros R1 es fenilo sustituido de 2 a 4 veces por halo o alcoxi C1-C6. Son compuestos especificos: N-[2-{6-[3-(2,6-dicloro-3,5-dimetoxi-feniI)-1-metil-ureido-pirimidin-4-ilamino}-fenil)-acrilamida N-[2-{6-[3-(2,6-dicloro-3,5-dimetoxi-fenil)-1-piridin-3-ilmetil-ureido]- pirimidin-4-ilamino}-fenil-acrilamida, entre otros. Tambien se refiere a una composicion farmaceutica y un metodo de tratamiento. Dichos compuestos son inhibidores de FGFR4 siendo utiles en el tratamiento de carcinoma hepatocelular
