STABLE ORAL ATORVASTATIN FORMULATION AND PROCESS OF ITS PREPARATION

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专利权人:

发明人:

AGARWAL RAJENDRA MURLIDHAR,GOGIA ASHISH

申请号：

IN2019/MUM/2008

公开号：

IN272594B

申请日:

2008.09.22

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

The present invention relates to a stable oral pharmaceutical formulations comprising amorphous atorvastatin calcium. The atorvastatin formulation prepared according to the present invention involves use minimum amount of pH adjusting substance preferably below 5%, more preferably below 4% by the total weight of the composition to obtain stable formulation. Further formulation provides a pH less than pKa+l of atorvastatin calcium to an aqueous solution and simultaneously improved solubility characteristics of atorvastatin calcium.

来源网站：

中国工程科技知识中心

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