ANGUS MACLEOD,DAVID MILLER,JIMMY VAN WILTENBURG,JONATHAN SHANNON,STEPHEN ST-GALLAY,STEPHEN THOM
申请号：
BR112020002906
公开号：
BR112020002906A2
申请日:
2018.08.15
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention relates to the compounds of the formula (i): formula (i), where q is selected from o or s； 1 is an optionally substituted optionally substituted saturated or unsaturated hydrocarbilene group including one or more n, o or s heteroatoms； r1 is? nr3r4,? or5,? (c = nr6) r7,? (co) r8,? cn,? n3, a quaternary ammonium group or an optionally substituted heterocycle； r3, r4, r5, r6, r7 and r8 are each, independently, hydrogen or an optionally substituted optionally substituted saturated or unsaturated hydrocarbyl group including one or more n, o or s heteroatoms； where optionally le r3, or le r4, or r3 and r4, or le r5, or le r6, or le r7, or r6 and r7, or le r8, together with the atom (s) at the which (s) they are attached to, can form an optionally substituted 3 to 12 membered saturated or unsaturated cyclic group； and r2 is a cyclic group substituted at position a, where r2 can optionally be additionally substituted； provided that the atom of 1 which is attached to the sulfur atom of the sulfonylurea group is a carbon atom and is not a ring atom of a heterocyclic or aromatic group. the present invention also relates to salts, solvates and prodrugs of these compounds, to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment and prevention of medical disorders and diseases, mainly by inhibiting nlrp3.a presente invenção refere-se aos compostos da fórmula (i): fórmula (i), em que q é selecionado dentre o ou s； l é um grupo hidrocarbileno c1-c12 saturado ou insaturado opcionalmente substituído opcionalmente incluindo um ou mais heteroátomos n, o ou s； r1 é ?nr3r4, ?or5, ?(c=nr6)r7, ?(co)r8, ?cn, ?n3, um grupo amônio quaternário ou um heterociclo opcionalmente substituído； r3, r4, r5, r6, r7 e r8 são, cada um, independentemente, hidrogênio ou um grupo hidrocarbila c1-c10 saturado ou insaturado opcionalmente substituído opcionalmente incluindo um ou mais heteroátomos n, o ou s； em que opcionalmente l e r3
