Andreas Arnell,Jose Jimenez,Rebecca Michael,Yvette Stallwood,Jesus Zurdo
申请号：
US14589066
公开号：
US09290563B2
申请日:
2015.01.05
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.
