PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating disorders characterized by proteinuria, such as diabetic nephropathy, Nephrotic syndromes (i.e. intrinsic renal failure), Nephritic syndromes, Toxic lesions of kidneys, Glomerular diseases such as membranous glomerulonephritis, Focal segmental glomerulosclerosis.SOLUTION: The invention provides a pharmaceutical composition which is an αvβ3 integrin inhibitor to reduce proteinuric associated with proteinuria, the pharmaceutical composition comprising cyclo-[Arg-Gly-Asp-D-Phe-Val] peptide comprising a RGD binding sequence.SELECTED DRAWING: None【課題】蛋白尿症として特徴付けられる糖尿病性腎症、ネフローゼ症候群（例えば、内因性腎不全）、腎炎症候群、腎臓の毒性病変、膜性糸球体腎炎のような糸球体疾患、巣状分節性糸球体硬化症等を治療する医薬組成物の提供。【解決手段】蛋白尿症に伴う蛋白尿を軽減するためのαｖβ３インテグリン阻害剤である、ＲＧＤ結合配列を含む環状［Ａｒｇ－Ｇｌｙ－Ａｓｐ－Ｄ－Ｐｈｅ－Ｖａｌ］ペプチドを含む医薬組成物。【選択図】なし
