Graham K. FARRINGTON,Alexey Alexandrovich LUGOVSKOY,Werner MEIER,John K. ELDREDGE,Ellen GARBER
申请号：
US12966541
公开号：
US20120003210A1
申请日:
2010.12.13
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The compositions and methods of the present invention are based, in part, on our discovery that an effector function mediated by an Fc-containing polypeptide can be altered by modifying one or more amino acid residues within the polypeptide (by, for example, electrostatic optimization). The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof.
