The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in inducing cell death and/or inhibiting the growth and/or proliferation of cells associated with a solid tumour, wherein the cells express IL1RAP. A related aspect of the invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in detecting pathological cells associated with a solid tumour, wherein the cells express IL1RAP. Further provided are pharmacological compositions comprising the agents of the invention and methods of using the same.La invención se refiere a un agente que comprende o consiste de un anticuerpo o un fragmento de unión a antígeno del mismo con especificidad para la proteína accesoria del receptor de interleucina-1 (IL1RAP) para usarse en el tratamiento o prevención de un tumor sólido en un paciente, en donde el tumor sólido comprende células que expresan IL1RAP, y en donde el agente induce muerte celular y/o inhibe el crecimiento y/o proliferación de células asociadas con el tumor sólido.
