Julien Alistair Brown,Daniel Christopher Brookings,Jag Paul Heer,James Andrew Johnson,Zhaoning Zhu
申请号:
US16487988
公开号:
US20200022988A1
申请日:
2018.03.14
申请国别(地区):
US
年份:
2020
代理人:
摘要:
A series of substituted fused pentacyclic imidazopyridine and imidazopyridazine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.