UTILISATION D'ANTICORPS ANTI-EGFR DANS LE TRAITEMENT DE MALADIE MEDIEE PAR DES MUTANTS DE RECEPTEUR DU FACTEUR DE CROISSANCE EPIDERMIQUE (EGFR)

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专利权人:

DANA-FARBER CANCER INSTITUTE; INC.

发明人:

WONG, KWOK-KIN,SCOTT, ANDREW MARK

申请号：

CA2676244

公开号：

CA2676244C

申请日:

2008.01.24

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention relates to the treatment of EGFR-mediated disease, particularly cancer, which is resistant to tyrosine kinase inhibitor therapies. Methods for treatment of cancer and reduction of tumor growth in individuals with secondary EGFR mutations, particularly tyrosine kinase domain mutations, resistant to standard therapy are provided. The invention provides methods for the treatment of tyrosine kinase inhibitor resistant cancers with anti-EGFR antibodies. Methods for treatment of recurrent lung cancer, including non-small cell lung carcinoma which is resistant to tyrosine kinase inhibitors, with the antibody anti-EGFR mAb806 are described.

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