The present invention relates to a temperature-sensitive hydrogel that encloses radioisotopes and chemotherapeutic agent for application in cancer treatment and manufacturing method thereof, in which cancer treatment agent, such as radio-therapeutic agent and chemotherapeutic agent, is uniformly enclosed in a hydrogel composed of polycaprolactone-polyethylene glycol-polycaprolactone. By taking advantage of the characteristic that the hydrogel is of a gel form at human body temperature and is a liquid as being preserved in low temperature, the cancer treatment agent can be smoothly injected to reach the location of tumor and is affected by human body temperature to keep in a gel form for realizing long term brachytherapy and greatly reducing the potential side effect caused by cancer treatment.本發明係關於一種應用於癌症治療之包覆放射性同位素與化療藥物之溫度敏感性水膠及其製備方法，其係將諸如核醫藥物或是化療藥物等癌症治療藥物均勻包覆於聚己內酯－聚乙二醇－聚己內酯所組成的水膠體中，藉由水膠體在人體溫度下呈膠態、在低溫保存下為液態之特性，使癌症治療藥物不但可以順利得注入抵達病灶腫瘤處，同時受人體體溫影響而凝為膠體，長效地進行近接治療，大幅降低癌症治療可能產生的副作用。
