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PHARMACEUTICAL COMPOSITION FOR TREATING EYE DRY AND / OR DAMAGE TO THE CONJUNCTIVES AND CORNITAS
专利权人:
Р-ТЕК УЕНО; ЛТД. (JP)
发明人:
МАСИМА Ёкихико (JP),КИСИМОТО Накаюки (JP),ТАБУТИ Рейко (JP),СИМА Наоко (JP)
申请号:
RU2015129822/15
公开号:
RU2015129822A
申请日:
2009.05.15
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A pharmaceutical composition for treating dry eye, which comprises recombinant human serum albumin obtained by recombinant yeast obtained by transforming yeast with the human serum albumin gene. The composition of claim 1, wherein the recombinant yeast is obtained by transforming a yeast of the genus Pichia or the genus Saccharomyces. 3. The composition of claim 1, wherein the yeast is Pichia pastoris or Saccharomyces cerevisiae. 4. The composition of claim 1, wherein the recombinant human serum albumin has the following properties: purity of the recombinant human serum albumin based on the total amount of the recombinant human serum albumin and impurities that originate from recombinant yeast cells consisting of proteins having antigenicity different from antigenicity human recombinant serum albumin, and polysaccharides, is more than 99.999%, and the total amount of impurities that come from recombinant yeast cells consisting of proteins having antigenicity different from the antigenicity of recombinant human serum albumin and polysaccharides are less than the detection limit of enzyme immunoassay (EIA) .5. The composition according to claim 1, intended for local instillation in the eye. 6. A composition according to claim 1, wherein the dry eye is dry eyes due to a deficiency of tear fluid or dry eyes due to excessive evaporation. The composition of claim 1, wherein the dry eye is selected from the group consisting of alacrimia, xerophthalmia, Schengen syndrome, dry keratoconjunctivitis, si1. Фармацевтическая композиция для лечения сухости глаз, которая включает рекомбинантный сывороточный альбумин человека, получаемый с помощью рекомбинантных дрожжей, получаемых с помощью трансформирования дрожжей геном сывороточного альбумина человека.2. Композиция по п. 1, в которой рекомбинантные дрожжи получают с помощью трансформирования дрожжей рода Pichia или рода Saccharomyces.3. Композиция по п. 1, в которой дрожжи представляют собой дрожжи Pichia pastoris или Sacchar
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