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PHARMACEUTICAL COMPOSITION FOR TREATING EYE DRY AND / OR DAMAGE TO THE CONJUNCTIVES AND CORNITAS
专利权人:
Р-ТЕК УЕНО; ЛТД. (JP)
发明人:
МАСИМА Ёкихико (JP),КИСИМОТО Накаюки (JP),ТАБУТИ Рейко (JP),СИМА Наоко (JP)
申请号:
RU2010151453/15
公开号:
RU2010151453A
申请日:
2009.05.15
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A pharmaceutical composition for treating dry eye, which comprises recombinant human serum albumin obtained by recombinant yeast obtained by transforming the yeast with the human serum albumin gene. ! 2. The composition according to claim 1, in which recombinant yeast is obtained by transforming a yeast of the genus Pichia or the genus Saccharomyces. ! 3. The composition according to claim 1, in which the yeast is a yeast Pichia pastoris or Saccharomyces cerevisiae. ! 4. The composition according to claim 1, in which recombinant human serum albumin has the following properties:! purity of recombinant human serum albumin based on the total amount of recombinant human serum albumin and impurities that come from recombinant yeast cells consisting of proteins having antigenicity different from the antigenicity of recombinant human serum albumin and polysaccharides is more than 99.999%, and! the total amount of impurities that come from recombinant yeast cells consisting of proteins having antigenicity different from the antigenicity of recombinant human serum albumin and polysaccharides is less than the detection limit of enzyme immunoassay (EIA). ! 5. The composition according to claim 1, intended for local instillation in the eye. ! 6. The composition according to claim 1, in which dry eye is dry eye due to deficiency of tear fluid or dry eye due to excessive evaporation. ! 7. The composition according to claim 1, in which dry eye is selected from the group consisting of alacrimia, xerophthalmia, Schengen syndrome, dry keratocon1. Фармацевтическая композиция для лечения сухости глаз, которая включает рекомбинантный сывороточный альбумин человека, получаемый с помощью рекомбинантных дрожжей, получаемых с помощью трансформирования дрожжей геном сывороточного альбумина человека. ! 2. Композиция по п.1, в которой рекомбинантные дрожжи получают с помощью трансформирования дрожжей рода Pichia или рода Saccharomyces. ! 3. Композиция по п.1, в которой дрожжи представляют
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