Compounds of formula (I) or a pharmaceutically acceptable salt thereof. wherein R is hydrogen or C1-4 alkyl； R1 is hydrogen, C1-4 alkyl, C(O)OH, C(O)NH2 or (C1-4 alkylene)R10； R2 and R3 are independently hydrogen, C1-4 alkyl or R2 together with R3 and together with the carbon atom to which they are attached form a C3-8 cycloalkyl group； R4 is C1-4 alkyl, C1-4 alkoxy or halogen； R5 and R7 are independently hydrogen, hydroxy, halogen, C(O)NH2, C(O)OH or (C1-4 alkylene)R10； R6 and R8 are independently hydrogen or halogen； R9 is hydrogen, (C1-4 alkylene)R10, C(O)NH2, C(O)OH or R9 together with R form a 6 membered heterocyclic ring optionally containing a further heteroatom selected from oxygen, sulphur or nitrogen； R10 is hydrogen, halogen, hydroxy, C(O)NH2, C(O)NH(C1-4 alkyl), C(O)N(C1-4 alkyl)2 or C(O)OH； n is 0, 1 or 2. processes for their preparation, to compositions containing them and to their use in the treatment of diseases and conditions for which antagonism of NK1 is beneficial.Jedinja formule (I) ili njegova farmaceutski prihvatljiva sogdeR je vodonik ili C1-4 alkil；R1 je vodonik, C1-4 alkil, C(O)OH, C(O)NH2 ili (C1-4 alkilen)R10；R2 i R3 su nezavisno vodonik, C1-4 alkil ili R2 zajedno sa R3 i zajedno sa atomom ugljenika za koji su vezani obrazuju C3-8 cikloalkil grupu；R4 je C1-4 alkil, C1-4 alkoksi ili halogen；R5 i R7 su nezavisno vodonik, hidroksi, halogen, C(O)NH2, C(O)OH ili (C1-4 alkilen) R10；R6 i R8 su nezavisno vodonik ili halogen；Rg je vodonik, (C1-4 alkilen)R10, C(O)NH2, C(O)OH orRg zajedno sa R obrazuje 6 člani heterociklični prsten koji po izboru sadrži heteroatom odabran od kiseonika, sumpora ili azota；R10 je vodonik, halogen, hidroksi, C(O)NH2, C(O)NH(C1-4 alkil), C(O)N(C1-4 alkil)2 ili C(O)OH；n je 0,1 ili 2.Prijava sadrži još 14 patentnih zahteva.
