The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.本發明大體上係關於用於T細胞活化及使其再定向至特定靶細胞的新穎雙特異性抗原結合分子。另外,本發明係關於編碼此類雙特異性抗原結合分子的聚核苷酸,以及包含此類聚核苷酸的載體及宿主細胞。本發明進一步關於製造本發明之雙特異性抗原結合分子的方法,及使用此等雙特異性抗原結合分子治療疾病的方法。
