Package systems that provide for prolonged shelf stability of sterilized cyanoacrylate compositions are provided. The package systems include an ampoule made from a material that is substantially impervious to gas and moisture penetration that includes a frangible foil seal, and an overpack. The ampoule contains a stabilized cyanoacrylate monomer composition, and may be sterilized by irradiation without substantially altering the viscosity of the composition. The package may be sterilized by ethylene oxide without substantially further altering the viscosity of the composition. The sterilized composition, when contained within the package system, is shelf-stable for a period of at least 24 months.
