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GAS-FILLED MICROVESICLES FOR USE AS VACCINE
专利权人:
发明人:
Gilles BIOLEY,Philippe BUSSAT,Blaise CORTHESY,Anne LASSUS
申请号:
US15536458
公开号:
US20170348401A1
申请日:
2015.12.21
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention, comprising a molar excess of fatty acids in the stabilizing envelope, are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.
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