POLYNUCLEOTIDES CODANT POUR L'INTERLEUKINE 12 (IL-12) ET LEURS UTILISATIONS

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专利权人:

INC.;MODERNATX

发明人:

FREDERICK, JOSHUA,HEWITT, SUSANNAH,BAI, AILIN,HOGE, STEPHEN,PRESNYAK, VLADIMIR,MCFADYEN, IAIN,BENENATO, KERRY,KUMARASINGHE, ELLALAHEWAGE SATHYAJITH

申请号：

CA3024470

公开号：

CA3024470A1

申请日:

2017.05.18

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional fragments thereof, and fusion proteins comprising IL12. In some embodiments, the open reading frame is sequence-optimized. In particular embodiments, the disclosure provides sequence-optimized polynucleotides comprising nucleotides encoding the polypeptide sequence of human IL12, or sequences having high sequence identity with those sequence optimized polynucleotides.

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