Stephen G. HOGE,Kerry BENENATO,Vladimir PRESNYAK,Iain MCFADYEN,Ellalahewage Sathyajith KUMARASINGHE,Staci SABNIS,William BUTCHER
申请号：
US16300223
公开号：
US20190382774A1
申请日:
2017.05.18
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention related to polyribonucleotides comprising an open reading frame of linked nucleosides encoding a polypeptide of interest (e.g., a therapeutic polypeptide), isoforms thereof, functional fragments thereof, and fusion proteins comprising the polypeptide. In some embodiments, the open reading frame is sequence-optimized. In particular embodiments, the invention provides sequence-optimized polyribonucleotides comprising nucleotides encoding the sequence of the polypeptide of interest, or sequence having high sequence identity with those sequence optimized polyribonucleotides.
