АМОРО Эдвин (US),ВАНАКЕРЕ Карел (BE),Уайт Майкл Эй. (US)
申请号：
RU2014145428/15
公开号：
RU2014145428A
申请日:
2010.11.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of cryogranulation of a pharmaceutical composition, which includes the following operations: creating a refrigerant stream； feeding the pharmaceutical composition to a dispensing device； distributing the pharmaceutical composition from the dispensing device to the refrigerant stream, the pharmaceutical composition being uniformly distributed over the flow of refrigerant and droplet size, allowing to form tablets in a given size range； separation of tablets from the refrigerant. 2. The method of claim 1, wherein supplying the pharmaceutical composition comprises feeding the pharmaceutical composition to a dispenser at a flow rate of about 0.5 to 10 liters per minute. The method of claim 1, wherein dispensing the pharmaceutical composition comprises dispensing the pharmaceutical composition through a plurality of distribution channels configured to form tablets of the pharmaceutical composition. A method according to claim 1, wherein the distribution of the pharmaceutical composition comprises the distribution of microparticles based on diketopiperazine in a fluid. A method according to claim 1, wherein the distribution of the pharmaceutical composition comprises the distribution of a pharmaceutical composition with a droplet size that allows the formation of tablets with dimensions of approximately 4 mm to 6 mm. A method according to claim 1, wherein the distribution of the pharmaceutical composition comprises distributing the pharmaceutical composition uniformly over the width of the refrigerant stream. The method according to claim 1, wherein the supply of the pharmaceutical composition comprises pumping the pharmaceutical composition from the reservoir and1. Способ криогрануляции фармацевтической композиции, который включает в себя следующие операции:создание потока хладагента；подача фармацевтической композиции в распределительное устройство；распределение фармацевтической композиции из распределительное устройство в поток хладагента, причем фармацевтич
