ANTI-CD154 ANTIBODY HAVING IMPROVED BINDING, FUNCTIONAL AND SAFETY CHARACTERISTICS AND USE IN HUMAN IMMUNOTHERAPY

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专利权人:

IMMUNEXT; INC.

发明人:

ROTHSTEIN, Jay,HOLGATE, Robert, George, Edward,HEARN, Arron

申请号：

PH12018500098

公开号：

PH12018500098A1

申请日:

2018.01.11

申请国别(地区):

PH

年份:

2018

代理人:

摘要：

Improved anti-CD154 antibodies are provided herein which have improved therapeutic potency, in vivo half-life and ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation, transplant recipients, fibrosis and allergic disorders is disclosed herein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/